HPVbase – a knowledgebase of viral integrations, methylation patterns and microRNAs aberrant expression: As potential biomarkers for Human papillomaviruses mediated carcinomas
Identifieur interne : 000049 ( Main/Exploration ); précédent : 000048; suivant : 000050HPVbase – a knowledgebase of viral integrations, methylation patterns and microRNAs aberrant expression: As potential biomarkers for Human papillomaviruses mediated carcinomas
Auteurs : Amit Kumar Gupta [Inde] ; Manoj Kumar [Inde]Source :
- Scientific Reports [ 2045-2322 ] ; 2015.
Abstract
Human papillomaviruses (HPVs) are extremely associated with different carcinomas. Despite consequential accomplishments, there is still need to establish more promising biomarkers to discriminate cancerous progressions. Therefore, we have developed HPVbase (
Url:
DOI: 10.1038/srep12522
PubMed: 26205472
PubMed Central: 4513345
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">HPVbase – a knowledgebase of viral integrations, methylation patterns and microRNAs aberrant expression: As potential biomarkers for Human papillomaviruses mediated carcinomas</title><author><name sortKey="Kumar Gupta, Amit" sort="Kumar Gupta, Amit" uniqKey="Kumar Gupta A" first="Amit" last="Kumar Gupta">Amit Kumar Gupta</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR)</institution>, Sector 39-A, Chandigarh; 160036,<country>India</country></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kumar, Manoj" sort="Kumar, Manoj" uniqKey="Kumar M" first="Manoj" last="Kumar">Manoj Kumar</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR)</institution>, Sector 39-A, Chandigarh; 160036,<country>India</country></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26205472</idno><idno type="pmc">4513345</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513345</idno><idno type="RBID">PMC:4513345</idno><idno type="doi">10.1038/srep12522</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000036</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000036</idno><idno type="wicri:Area/Pmc/Curation">000036</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000036</idno><idno type="wicri:Area/Pmc/Checkpoint">000035</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000035</idno><idno type="wicri:Area/Ncbi/Merge">000233</idno><idno type="wicri:Area/Ncbi/Curation">000233</idno><idno type="wicri:Area/Ncbi/Checkpoint">000233</idno><idno type="wicri:Area/Main/Merge">000048</idno><idno type="wicri:Area/Main/Curation">000049</idno><idno type="wicri:Area/Main/Exploration">000049</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">HPVbase – a knowledgebase of viral integrations, methylation patterns and microRNAs aberrant expression: As potential biomarkers for Human papillomaviruses mediated carcinomas</title><author><name sortKey="Kumar Gupta, Amit" sort="Kumar Gupta, Amit" uniqKey="Kumar Gupta A" first="Amit" last="Kumar Gupta">Amit Kumar Gupta</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR)</institution>, Sector 39-A, Chandigarh; 160036,<country>India</country></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kumar, Manoj" sort="Kumar, Manoj" uniqKey="Kumar M" first="Manoj" last="Kumar">Manoj Kumar</name><affiliation wicri:level="1"><nlm:aff id="a1"><institution>Bioinformatics Centre, Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR)</institution>, Sector 39-A, Chandigarh; 160036,<country>India</country></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Human papillomaviruses (HPVs) are extremely associated with different carcinomas. Despite consequential accomplishments, there is still need to establish more promising biomarkers to discriminate cancerous progressions. Therefore, we have developed HPVbase (<ext-link ext-link-type="uri" xlink:href="http://crdd.osdd.net/servers/hpvbase/">http://crdd.osdd.net/servers/hpvbase/</ext-link>), a comprehensive resource for three major efficacious cancer biomarkers i.e. integration and breakpoint events, HPVs methylation patterns and HPV mediated aberrant expression of distinct host microRNAs (miRNAs). It includes clinically important 1257 integrants and integration sites from different HPV types i.e. 16, 18, 31, 33 and 45 associated with distinct histological conditions. An inclusive HPV integrant and breakpoints browser was designed to provide easy browsing and straightforward analysis. Our study also provides 719 major quantitative HPV DNA methylation observations distributed in 5 distinct HPV genotypes from higher to lower in numbers namely HPV 16 (495), HPV 18 (113), HPV45 (66), HPV 31 (34) and HPV 33 (11). Additionally, we have curated and compiled clinically significant aberrant expression profile of 341 miRNAs including their target genes in distinct carcinomas, which can be utilized for miRNA therapeutics. A user-friendly web interface has been developed for easy data retrieval and analysis. We foresee that HPVbase an integrated and multi-comparative platform would facilitate reliable cancer diagnostics and prognosis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="De Villiers, E M" uniqKey="De Villiers E">E. M. de Villiers</name></author><author><name sortKey="Fauquet, C" uniqKey="Fauquet C">C. Fauquet</name></author><author><name sortKey="Broker, T R" uniqKey="Broker T">T. R. 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